Facilty improvements include:

• January 2009: DePaul opened the $40 million Monsignor Andrew J. McGowan Science Building at 1110 W. Belden Ave. on the Lincoln Park Campus. The 130,000-square foot, four-story structure houses 28 research and teaching laboratories, a lecture hall and two tiered classrooms, and a multipurpose room that converts from a classroom to a lab. The roof supports two greenhouses - one for teaching and one for research. The facility is a core component of DePaul's $20 million Campaign for Excellence in Science, designed to educate professionals to meet the needs of Illinois' scientific and medical communities.  The building is named for the brother of William G. McGowan, the late founder of MCI Communications and the namesake for DePaul's first science building, which was completed in 1998 and lies just north of the new building.
              
• June 2008: DePaul University expanded its Loop Campus by acquiring the historic 14 E. Jackson Blvd. building, an 18-story, 384,000-square-foot structure located across the street from the university’s DePaul Center.  DePaul's School for New Learning and College of Communication are housed in the building.  With the acquisition, DePaul became the institution of higher education with the most square footage of space in the South Loop academic corridor.

• September 2007: DePaul completed $9 million in renovations at two Lincoln Park Campus academic buildings, the Thomas Levan Center, 2322 N. Kenmore Ave., and the Michael J. O'Connell Center, 1036 W. Belden Ave. The project included installation of 29 high-tech classrooms.

• January 2006: DePaul gave a $3 million facelift to the venerable Cortelyou Commons in Lincoln Park by adding an outdoor terrace on the west side of the building facing Wish Field, installing air conditioning, restoring existing wood paneling and upgrading restrooms

• October 2005: The College of Law cut the ribbon on a $1 million, 3,200-square-foot admission center that gives the law school an important first-floor presence at the corner of Jackson Boulevard and Wabash Avenue in downtown Chicago. Meanwhile, within the DePaul Center, the university dedicated the new Joan M. Wish Welcome Center. The 2,000-square-foot facility serves as the point of first contact on the Loop Campus for prospective undergraduate students.

• September 2005: Five brownstones on Racine Avenue between Belden and Fullerton avenues on the Lincoln Park Campus were renovated to accommodate the Humanities Center and the religious studies and anthropology departments in a $2 million project that converted former student residences into faculty offices.

• August 2005: DePaul invested $1.6 million to upgrade Wish Field and $3.5 million for Cacciatore Stadium on the Lincoln Park Campus. An innovative "removable tray" system of artificial turf – designed to cover and protect the clay softball infield when the field is being used for men's and women's soccer games – was installed. Additionally, five square yards was added to the soccer field, making it 70 yards by 115 yards to meet NCAA standards. Cacciatore Stadium became the new home for the women's softball program. New seating for 800 spectators, a press and scorekeeper's box and team benches were added, and improvements were made to the bullpens, dugouts, batting cages and field.

• June 2005: DePaul and Barnes & Noble College Booksellers Inc. opened a two-level "academic superstore" in the DePaul Center on the Loop Campus, providing textbook services for DePaul and a retail book store for the community. Barnes & Noble also assumed management of the Lincoln Park Campus bookstore.

• August 2004: University Center of Chicago, the largest multi-college residence hall in the nation, opened. The $150-million, 18-story facility at State Street and Congress Parkway houses 1,700 students from DePaul, Roosevelt University, Columbia College Chicago and other institutions, as well as retail space. The facility is owned by the Educational Advancement Fund, a non-profit entity formed by the three South Loop educational institutions. In October 2004, University Center of Chicago was named Residential/Housing Project of the Year by Midwest Construction magazine, a regional trade publication for the construction industry.

• January 2002: DePaul opened its $25 million student center at Sheffield and Belden avenues on the Lincoln Park Campus. The 145,000-square-foot facility houses student services, organization offices and event space.
  
• September 2000: At the cost of $36.4 million, two new coed residence halls, the Belden/Racine Hall at 2311 N. Racine Ave. and the Clifton/Fullerton Hall at 2350 N. Clifton St., were opened. The new facilities and the rehabbed Munroe Hall at 2312 N. Clifton St. added 588 student beds to the Lincoln Park Campus and created a new student community named West Village.

• May 2000: The $10 million DePaul Athletic Center, 2323 N. Sheffield Ave., opened, replacing the 43-year-old Alumni Hall. The facility serves as a practice, training and fitness center for student athletes on DePaul's teams, including the Blue Demon men's and women's basketball teams. The women's basketball and volleyball teams compete in the facility's 3,000-seat arena.

• November 1999: DePaul opened a $7 million, 518-car parking facility at 2330 N. Clifton Ave.

• September 1999: The $13 million Ray Meyer Fitness and Recreation Center opened its doors at 2235 N. Sheffield Ave. The four-level, 120,000-square-foot facility provides an expanded venue for intramural and club sports, wellness activities and fitness programs for students, staff, faculty and alumni.

• September 1998: The $10 million Centennial Hall opened at 2345 N. Sheffield Ave. The mixed-use building of 88,635 gross square feet contains a residence hall and 28,000 square feet of retail that includes a two-story Dominick's food store.

• August 1998: DePaul dedicated the $12 million William G. McGowan Biological and Environmental Sciences Center at 2335 N. Clifton Ave. The 60,000-square-foot facility provides seven modern biological and environmental sciences teaching laboratories for students.

• September 1993: DePaul dedicated the 11-story DePaul Center, a $70 million renovation of the historic former Goldblatt's department store at 1 E. Jackson. The mixed-use project created an anchor for DePaul's Loop Campus, combining academic space (including the College of Commerce), with retail and City of Chicago office space . In November of 2000, the Urban Land Institute presented the DePaul Center with its prestigious Award for Excellence for Rehabilitation.

• September 1992: DePaul opened its first free-standing library, a $25 million building at 2350 N. Kenmore Ave. It was named the John T. Richardson Library in 1993 in honor of the university's ninth president.